Every day, there seems to be a replacement article about the growing popularity of CBD oil. Some articles speculate on the big economic process that’s expected from CBD products over the subsequent few years, while others specialize in CBD’s potential for reducing chronic pain and alleviating anxiety. The third sort of article comes from researchers who cite discrepancies between users’ glowing accounts and clinical testing that doesn’t support these anecdotes.
So is CBD oil a huge hype or a science-based gift from nature? And if it happens to be the latter, what’s the simplest thanks to maximize its effects?
What Is CBD and What Does It Do?
CBD (short for cannabidiol) may be a substance extracted from the flower and leaves of the hemp plant. Discovered within the 1940s, CBD is one of over 100 identified cannabinoids within the Cannabis plant, accounting for up to 40% of the plant’s extract. Unlike another prevalent cannabinoid (THC), CBD doesn’t appear to make the psychoactive effects related to marijuana (1, 2).
The bulk of the research on CBD has focused on its ability to affect cell metabolism through what’s called the endocannabinoid system. This technique is involved during a wide selection of physiological functions, including the regulation of our mood, inflammation response, system, and metabolism.
The precise mechanisms of how CBD works aren’t entirely clear; However, the most hypothesis is that CBD features a significant influence on the
What Are Endocannabinoids?
Found in every organ and tissue of the body, endocannabinoids are important lipids made naturally from the cells’ content of omega-3s and omega-6s. These lipids stimulate specialized cell wall receptors, which successively prompt the cell to perform specific tasks.
For instance, when certain sorts of endocannabinoids activate the endocannabinoid receptor CB1, the cell increases energy storage. Similarly, when endocannabinoids activate another receptor (CB2), they assist to scale back pro-inflammatory cytokines (3). Note: These are equivalent receptors that cannabinoids (like CBD) act on, too.
THC, CBD, and CBN are three cannabinoids found in Cannabis. Mimicking the body’s endocannabinoids, they “unlock” the receptors CB1 and CB2, creating a spread of effects.
There are numerous sorts of endocannabinoids and endocannabinoid receptors, all of which have multiple impacts on the cells. Therefore, it is often incredibly difficult to generalize about their effects. However, this multi-purpose functionality helps to elucidate why the endocannabinoid system is believed to possess an influence on many various diseases and health conditions.
How Are Omega-3s Connected to the Endocannabinoid System?
As mentioned above, endocannabinoids are lipids made up of the cells’ omega-3 and omega-6 content. Once cells build up a sufficient inventory of those fatty acids, endocannabinoids are created rapidly and as-needed in response to brain activity and stimuli (like stress and exercise).
Omega-3s are directly involved within the synthesis of endocannabinoids, and also react with existing endocannabinoids to make omega-3-derived endocannabinoid epoxides (which have powerful anti-inflammatory properties)(4). Thanks to the important role that omega-3s have within the cell wall, researchers believe that omega-3s also function crucial anchors for endocannabinoid cell wall receptors (5).
To put it simply, omega-3s and endocannabinoids are totally hooked into one another during a healthy brain and body. This connection also can help explain why the noted anxiety and pain-relieving effects from taking CBD oil are almost like the results achieved from receiving adequate omega-3 supplementation over time (6).
What Happens once you Don’t Get Enough Omega-3s?
Omega-3 deficiency is widespread in today’s world, impacting some 95% of adults within us (7). As researchers have demonstrated, this deficiency has serious consequences for the healthy functioning of our endocannabinoid systems.
Omega-3-deficient diets don’t just limit the creation of beneficial endocannabinoids and therefore the omega-3-derived endocannabinoid epoxides. Studies have also shown that omega-3-deficiency creates dysfunctional endocannabinoid receptors, uncoupling them from the protein and altering signaling pathways within the brain (8).
Health Consequences of Omega-3 Deficiency
Consequences of dysfunctional endocannabinoid receptors (due to omega-3 deficiency) include increased anxiety and impaired behavior, consistent with one mice study from the University of Bordeaux (9). Additionally, studies also show that omega-3 deficiency plays a task in increasing the event of obesity through the dysregulation of the endocannabinoid system (10).
Chronic deficiency of omega-3s in our diet may partly explain society’s enormous looking for CBD products. What’s more, it’s going to also help to elucidate the widely-diverse experiences that CBD users have. After all, if one person’s endocannabinoid receptors are dysfunctional, throwing many cannabinoids at them won’t necessarily produce the results users hope to realize.
While more research is required to deal with these important topics, the above studies raise pressing questions.
Most people within us don’t get enough omega-3s, either from diet or supplements. This is often in stark contrast with other countries, like Japan, where omega-3 intakes are much higher.
Why Do People Prefer CBD to Omega-3 Supplements?
Considering the deep involvement of omega-3s within the endocannabinoid system, you’d think that anyone fascinated by CBD’s effects would even have a dual interest in animal oil. However, in comparison to most omega-3 supplements, CBD has clear advantages.
While CBD’s effects appear quickly, omega-3s take longer to figure – often many weeks of consistent consumption. These rapid effects probably explain why CBD is creating such a buzz. With CBD products, people also are willing to require an adequate dose, but that always isn’t the case with omega-3 products.
Many people have asked us if we make any products with CBD oil in them, but as of the time of publication, we do not. Please also note that the FDA has made it clear that combining CBD into existing supplements is currently not allowed.
Is CBD a Panacea?
Some years ago, I attended a gathering on the consequences of a replacement molecule that had the potential for treating Alzheimer’s. The presentation was inspiring and left attendees with a sense that this new molecule might be a serious therapeutic tool.
Afterward, I had the prospect to debate science with the presenter one-on-one.
“Do you think that one molecule will do the entire trick in curing or preventing this disease,” I asked.
“Of course not,” he answered. “But the investors may believe it.”
Most physiologists and biologists know that single molecules are rarely a cure-all for complex health issues. Unfortunately, now often gets missed once we get too focused on isolated substances — either due to the pharmaceutical industry’s desire for patentable products or the appeal of easily understandable buzzwords. The physical body and cell metabolism are extremely complex and dependent upon the interactions of a mess of things (e.g. genes, environment, nutrition, microbiome, age, gender, etc). Therefore, it’s highly unlikely that changing only one factor will solve chronic conditions for many people.
There isn’t one substance – whether that’s CBD or maybe omega-3s – which will ever give us a one-way ticket to healthiness. But once we understand the underlying mechanisms of the body and use a synergy of wholesome efforts, we’ll be ready to carve a far better path forward.
This is the philosophy that guides us at Omega3 Innovations. It’s the rationale we’ve created a full-spectrum oil, and therefore the reason we’re hooked into the mixture of our Omega Cure oil with melatonin and vitamin D3. It’s why we care about not just increasing our consumption of omega-3s, but also decreasing our intake of omega-6s, and why we wish to share advice about the way to improve sleep hygiene.
Combination therapy, in our book, is where the most important medical innovation will come from within the future, and we’re excited to be exploring these principles as a corporation.